Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC6909190 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Zhao Yue Y Zhu Qin Q Bu Xiumin X Zhou Yihui Y Bai Dongsheng D Guo Qinglong Q Gao Yuan Y Lu Na N
Redox biology 20191128
Emerging evidence suggests that oroxylin A exhibits antitumor effects by inducing cell apoptosis. However, the involved molecular mechanisms have not been elucidated. Here we report that the apoptosis induced by oroxylin A was dependent on p62-mediated activation of caspase-8 in hepatocellular carcinoma cells. Furthermore, oroxylin A also caused p62/SQSTM1 proteolysis at Asp329 by activating caspase-8. Further studies confirm that mutation in p62 (D329H and D329G) was resistant to oroxylin A-med ...[more]