Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?

ABSTRACT:

Background and purpose

We investigated how features relating to pelvic cavity anatomy and tumor hemodynamic factors may influence systemic failure in rectal cancer.

Materials and methods

Rectal cancer patients (207 women, 343 men), who had been prospectively enrolled onto six cohorts and given curative-intent therapy, were analyzed for the first metastatic event. In one of the cohorts, the diameter of the inferior mesenteric vein (IMV) was assessed on diagnostic abdominal computed tomography images (n = 113). Tumor volume (n = 193) and histologic response to neoadjuvant therapy (n = 445) were recorded from diagnostic magnetic resonance images and surgical specimens, respectively.

Results

More women than men developed lung metastasis (p = 0.037), while the opposite was

SUBMITTER: Meltzer S 

PROVIDER: S-EPMC6909215 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature