Ontology highlight
ABSTRACT:
SUBMITTER: Damm G
PROVIDER: S-EPMC6909377 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
EXCLI journal 20191118
Primary human hepatocytes (PHHs) remain the gold standard for <i>in vitro</i> investigations of xenobiotic metabolism and hepatotoxicity. However, scarcity of liver tissue and novel developments in liver surgery has limited the availability and quality of tissue samples. In particular, warm ischemia shifts the intracellular metabolism from aerobic to anaerobic conditions, which increases glycogenolysis, glucose depletion and energy deficiency. Therefore, the aim of the present study was to inves ...[more]