Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6909602 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Li Yuanyuan Y Niu Mengyue M Zhao Aonan A Kang Wenyan W Chen Zhichun Z Luo Ningdi N Zhou Liche L Zhu Xiongwei X Lu Liming L Liu Jun J
Journal of neuroinflammation 20191212 1
<h4>Background</h4>The mechanisms underlying the pathogenesis and progression of Parkinson's disease (PD) remain elusive, but recent opinions and perspectives have focused on whether the inflammation process induced by microglia contributes to α-synuclein-mediated toxicity. Migration of microglia to the substantia nigra (SN) could precede neurodegeneration in A53T mice. We hypothesized that CXCL12 could be a mediator in the α-synuclein-induced migration of microglia.<h4>Methods</h4>After establi ...[more]