Ontology highlight
ABSTRACT:
SUBMITTER: Lee JY
PROVIDER: S-EPMC6909891 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Lee Jin Young JY Kennedy Brian K BK Liao Chen-Yu CY
The journals of gerontology. Series A, Biological sciences and medical sciences 20200101 1
The mechanistic target of rapamycin (mTOR) is an essential nutrient-sensing kinase that integrates and regulates a number of fundamental cellular processes required for cell growth, cell motility, translation, metabolism, and autophagy. mTOR signaling has been implicated in the progression of many human diseases, and its dysregulation has been reported in several pathological processes, especially in age-related human diseases and mouse models of accelerated aging. In addition, many studies have ...[more]