Ontology highlight
ABSTRACT:
SUBMITTER: Sakalauskas A
PROVIDER: S-EPMC6910113 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Sakalauskas Andrius A Ziaunys Mantas M Smirnovas Vytautas V
PeerJ 20191210
Protein aggregation into highly structured fibrils has long been associated with several neurodegenerative disorders, such as Alzheimer's or Parkinson's disease. Polymorphism of amyloid fibrils increases the complexity of disease mechanisms and may be one of the reasons for the slow progress in drug research. Here we report protein concentration as another factor leading to polymorphism of insulin amyloid fibrils. Moreover, our data suggests that insulin amyloid conformation can self-replicate o ...[more]