Ontology highlight
ABSTRACT:
SUBMITTER: Greene ER
PROVIDER: S-EPMC6910829 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Greene Eric R ER Goodall Ellen A EA de la Peña Andres H AH Matyskiela Mary E ME Lander Gabriel C GC Martin Andreas A
eLife 20191128
The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasome's regulatory particle, consisting of lid and base subcomplexes, undergoes major conformational changes whose origin is unknown. Investigating the <i>Saccharomyces cerevisiae</i> proteasome, we found that peripheral interactions between the lid subunit Rpn5 and the base AAA+ ATPase rin ...[more]