Ontology highlight
ABSTRACT:
SUBMITTER: Munk C
PROVIDER: S-EPMC6910865 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Munk Christian C Harpsøe Kasper K Hauser Alexander S AS Isberg Vignir V Gloriam David E DE
Current opinion in pharmacology 20160729
G protein-coupled receptors (GPCRs) represent the largest family of human membrane proteins, as well as drug targets. A recent boom in GPCR structural biology has provided detailed images of receptor ligand binding sites and interactions on the molecular level. An ever-increasing number of ligands is reported that exhibit activity through multiple receptors, binding in allosteric sites, and bias towards different intracellular signalling pathways. Furthermore, a wealth of single point mutants ha ...[more]