Ontology highlight
ABSTRACT:
SUBMITTER: Bechynska K
PROVIDER: S-EPMC6910966 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Bechynska Kamila K Daskova Nikola N Vrzackova Nikola N Harant Karel K Heczková Marie M Podzimkova Katerina K Bratova Miriam M Dankova Helena H Berkova Zuzana Z Kosek Vit V Zelenka Jaroslav J Hajslova Jana J Sedlacek Radislav R Suttnar Jiri J Hlavackova Alzbeta A Bartonova Lenka L Cahova Monika M
Scientific reports 20191213 1
Parenteral nutrition (PN) is often associated with the deterioration of liver functions (PNALD). Omega-3 polyunsaturated fatty acids (PUFA) were reported to alleviate PNALD but the underlying mechanisms have not been fully unraveled yet. Using omics´ approach, we determined serum and liver lipidome, liver proteome, and liver bile acid profile as well as markers of inflammation and oxidative stress in rats administered either ω-6 PUFA based lipid emulsion (Intralipid) or ω-6/ω-3 PUFA blend (Intra ...[more]