Ontology highlight
ABSTRACT:
SUBMITTER: Pollock K
PROVIDER: S-EPMC6911004 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Pollock Katie K Liu Manjuan M Zaleska Mariola M Meniconi Mirco M Pfuhl Mark M Collins Ian I Guettler Sebastian S
Scientific reports 20191213 1
The PARP enzyme and scaffolding protein tankyrase (TNKS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby controls diverse cellular functions. A number of these are implicated in cancer-relevant processes, including Wnt/β-catenin signalling, Hippo signalling and telomere maintenance. The ARCs recognise a conserved tankyrase-binding peptide motif (TBM). All currently available tankyrase inhibitors target the catalytic domain and inhibit tankyrase's poly( ...[more]