Ontology highlight
ABSTRACT:
SUBMITTER: Georgiadou D
PROVIDER: S-EPMC6911039 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Georgiadou Danai D Boussata Souad S Ranzijn Willemijn H M WHM Root Leah E A LEA Hillenius Sanne S Bij de Weg Jeske M JM Abheiden Carolien N H CNH de Boer Marjon A MA de Vries Johanna I P JIP Vrijkotte Tanja G M TGM Lambalk Cornelis B CB Kuijper Esther A M EAM Afink Gijs B GB van Dijk Marie M
Scientific reports 20191213 1
Preeclampsia is a frequent gestational hypertensive disorder with equivocal pathophysiology. Knockout of peptide hormone ELABELA (ELA) has been shown to cause preeclampsia-like symptoms in mice. However, the role of ELA in human placentation and whether ELA is involved in the development of preeclampsia in humans is not yet known. In this study, we show that exogenous administration of ELA peptide is able to increase invasiveness of extravillous trophoblasts in vitro, is able to change outgrowth ...[more]