Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.
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ABSTRACT:
SUBMITTER: Michalovich D
PROVIDER: S-EPMC6911092 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.
Michalovich David D Rodriguez-Perez Noelia N Smolinska Sylwia S Pirozynski Michal M Mayhew David D Uddin Sorif S Van Horn Stephanie S Sokolowska Milena M Altunbulakli Can C Eljaszewicz Andrzej A Pugin Benoit B Barcik Weronika W Kurnik-Lucka Magdalena M Saunders Ken A KA Simpson Karen D KD Schmid-Grendelmeier Peter P Ferstl Ruth R Frei Remo R Sievi Noriane N Kohler Malcolm M Gajdanowicz Pawel P Graversen Katrine B KB Lindholm Bøgh Katrine K Jutel Marek M Brown James R JR Akdis Cezmi A CA Hessel Edith M EM O'Mahony Liam L
Nature communications 20191213 1
In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute to disease phenotypes, such as obese asthmatics or severe asthmatics, are required. Here we report immunological and microbiome alterations in obese asthmatics (n = 50, mean age = 45), non-obese asthmatics (n = 53, mean age = 40), obese non-asthmatics (n = 51, mean age = 44) and their healthy counterparts (n = 48, mean age = 39). Obesity is associated wit ...[more]
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