Ontology highlight
ABSTRACT:
SUBMITTER: Brison O
PROVIDER: S-EPMC6911102 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Brison Olivier O El-Hilali Sami S Azar Dana D Koundrioukoff Stéphane S Schmidt Mélanie M Nähse Viola V Jaszczyszyn Yan Y Lachages Anne-Marie AM Dutrillaux Bernard B Thermes Claude C Debatisse Michelle M Chen Chun-Long CL
Nature communications 20191213 1
Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in large expressed genes, suggesting that transcription could elicit their instability; however, the underlying mechanisms remain elusive. Genome-wide replication timing analyses here show that stress-induced delayed/under-replication is the hallmark of CFSs. Extensive genome-wide analyses of nascent transcripts, replication orig ...[more]