Ontology highlight
ABSTRACT:
SUBMITTER: McMurran CE
PROVIDER: S-EPMC6911206 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
McMurran Christopher E CE Guzman de la Fuente Alerie A Penalva Rosana R Ben Menachem-Zidon Ofra O Dombrowski Yvonne Y Falconer John J Gonzalez Ginez A GA Zhao Chao C Krause Fynn N FN Young Adam M H AMH Griffin Julian L JL Jones Clare A CA Hollins Claire C Heimesaat Markus M MM Fitzgerald Denise C DC Franklin Robin J M RJM
Proceedings of the National Academy of Sciences of the United States of America 20191118 50
The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress toward therapies that modulate the microbiota with the aim of limiting immune-mediated demyelination, as occurs in multiple sclerosis. However, remyelination-the regeneration of myelin sheaths-also depends upon an immune response, and the effects that such interventions might have on remyelination have not yet been explored. Here, we show that ...[more]