Ontology highlight
ABSTRACT:
SUBMITTER: Hollern DP
PROVIDER: S-EPMC6911685 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Hollern Daniel P DP Xu Nuo N Thennavan Aatish A Glodowski Cherise C Garcia-Recio Susana S Mott Kevin R KR He Xiaping X Garay Joseph P JP Carey-Ewend Kelly K Marron David D Ford John J Liu Siyao S Vick Sarah C SC Martin Miguel M Parker Joel S JS Vincent Benjamin G BG Serody Jonathan S JS Perou Charles M CM
Cell 20191101 5
This study identifies mechanisms mediating responses to immune checkpoint inhibitors using mouse models of triple-negative breast cancer. By creating new mammary tumor models, we find that tumor mutation burden and specific immune cells are associated with response. Further, we developed a rich resource of single-cell RNA-seq and bulk mRNA-seq data of immunotherapy-treated and non-treated tumors from sensitive and resistant murine models. Using this, we uncover that immune checkpoint therapy ind ...[more]