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Ketone bodies, stress response, and redox homeostasis.

ABSTRACT: The ketone body β-hydroxybutyrate is no longer viewed simply as a metabolic intermediate, as it regulates a broad range of physiological processes at cellular and systemic levels. Particularly, β-hydroxybutyrate functions as a stress response molecule and orchestrates an antioxidant defense program to maintain redox homeostasis in response to environmental and metabolic challenges, such as ischemia. This property of β-hydroxybutyrate might be key for the beneficial effect of calorie restriction on stress response and disease processes.

SUBMITTER: Rojas-Morales P

PROVIDER: S-EPMC6911969 | biostudies-literature |

REPOSITORIES: biostudies-literature

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