Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is Best.
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ABSTRACT:
SUBMITTER: Santos-Sacchi J
PROVIDER: S-EPMC6911985 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is Best.
Santos-Sacchi Joseph J Tan Winston W
iScience 20191125
Cochlear amplification denotes a boost to auditory sensitivity and selectivity that is dependent on outer hair cells from Corti's organ. Voltage-driven electromotility of the cell is believed to feed energy back into the cochlear partition via a cycle-by-cycle mechanism at very high acoustic frequencies. Here we show using wide-band macro-patch voltage-clamp to drive prestin, the molecular motor underlying electromotility, that its voltage-sensor charge movement is unusually low pass in nature, ...[more]
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