Unknown

Dataset Information

0

Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is Best.


ABSTRACT: Cochlear amplification denotes a boost to auditory sensitivity and selectivity that is dependent on outer hair cells from Corti's organ. Voltage-driven electromotility of the cell is believed to feed energy back into the cochlear partition via a cycle-by-cycle mechanism at very high acoustic frequencies. Here we show using wide-band macro-patch voltage-clamp to drive prestin, the molecular motor underlying electromotility, that its voltage-sensor charge movement is unusually low pass in nature, being incapable of following high-frequency voltage changes. Our data are incompatible with a cycle-by-cycle mechanism responsible for high-frequency tuning in mammals.

SUBMITTER: Santos-Sacchi J 

PROVIDER: S-EPMC6911985 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC2862844 | biostudies-literature
| S-EPMC2435065 | biostudies-literature
| S-EPMC1863495 | biostudies-literature
| S-EPMC3143834 | biostudies-literature
| S-EPMC1190179 | biostudies-literature
| S-EPMC4282873 | biostudies-literature
| S-EPMC8674105 | biostudies-literature
| S-EPMC2753271 | biostudies-literature
| S-EPMC9276951 | biostudies-literature
| S-EPMC2686157 | biostudies-literature