Dataset Information

Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex.

ABSTRACT: Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.

SUBMITTER: Tresserra-Rimbau A

PROVIDER: S-EPMC6912253 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex.

Tresserra-Rimbau Anna A Castro-Barquero Sara S Vitelli-Storelli Facundo F Becerra-Tomas Nerea N Vázquez-Ruiz Zenaida Z Díaz-López Andrés A Corella Dolores D Castañer Olga O Romaguera Dora D Vioque Jesús J Alonso-Gómez Ángel María ÁM Wärnberg Julia J Martínez José Alfredo JA Serra-Majem Lluís L Estruch Ramon R Tinahones Francisco José FJ Lapetra José J Pintó Xavier X Tur Josep Antoni JA López-Miranda José J García-Molina Laura L Delgado-Rodríguez Miguel M Matía-Martín Pilar P Daimiel Lidia L Rubín-García María M Vidal Josep J Galdon Alba A Ros Emilio E Basterra-Gortari Francisco Javier FJ Babio Nancy N Sorlí José Vicente JV Hernáez Álvaro Á Konieczna Jadwiga J Notario-Barandiaran Leyre L Tojal-Sierra Lucas L Pérez-López Jessica J Abete Itziar I Álvarez-Pérez Jacqueline J Fernández-García José Carlos JC Santos-Lozano José Manuel JM Galera-Cusí Ana A Julibert Alicia A Ruiz-Canela Miguel M Martinez-Lacruz Raul R Pérez-Vega Karla-Alejandra KA Galmes-Panades Aina María AM Pastor-Polo Concepción C Moreno-Rodriguez Anai A Gea Alfredo A Fitó Montserrat M Lamuela-Raventós Rosa María RM Salas-Salvadó Jordi J

Antioxidants (Basel, Switzerland) 20191108 11

Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syn ...[more]

PMID: 31717390

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Dataset Information

Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex.

Publications

Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex.

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