Ontology highlight
ABSTRACT:
SUBMITTER: Costamagna G
PROVIDER: S-EPMC6912470 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Costamagna Gianluca G Andreoli Luca L Corti Stefania S Faravelli Irene I
Cells 20191114 11
Induced pluripotent stem cells (iPSCs)-based two-dimensional (2D) protocols have offered invaluable insights into the pathophysiology of neurological diseases. However, these systems are unable to reproduce complex cytoarchitectural features, cell-cell and tissue-tissue interactions like their in vivo counterpart. Three-dimensional (3D)-based culture protocols, though in their infancy, have offered new insights into modeling human diseases. Human neural organoids try to recapitulate the cellular ...[more]