Ontology highlight
ABSTRACT:
SUBMITTER: Smith-Cohn M
PROVIDER: S-EPMC6912849 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Smith-Cohn Matthew M Davidson Christian C Colman Howard H Cohen Adam L AL
CNS oncology 20191210 4
<b>Aim:</b> Therapeutic targeting of <i>BRAF</i> alterations in primary brain tumor patients has demonstrated clinical activity in case reports and early trials; however, there is limited high-level evidence of the efficacy. <b>Patients & results:</b> Targeting <i>BRAF</i> V600E mutations with concurrent dabrafenib and trametinib in anaplastic pleomorphic xanthoastrocytoma resulted in a transient radiographic and clinical response and no therapeutic benefit in a patient with an epithelioid gliob ...[more]