Ontology highlight
ABSTRACT:
SUBMITTER: Long DD
PROVIDER: S-EPMC6912869 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20191126 12
The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed to a growing opioid epidemic in the United States. Gastrointestinal dysfunction is an additional serious consequence of opioid use, and this can be treated with a localized drug distribution of a non-CNS penetrant, peripherally restricted opioid receptor antagonist. Herein, we describe the application of Ther ...[more]