Pushing the envelope: LPS modifications and their consequences.
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ABSTRACT:
SUBMITTER: Simpson BW
PROVIDER: S-EPMC6913091 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Pushing the envelope: LPS modifications and their consequences.
Simpson Brent W BW Trent M Stephen MS
Nature reviews. Microbiology 20190701 7
The defining feature of the Gram-negative cell envelope is the presence of two cellular membranes, with the specialized glycolipid lipopolysaccharide (LPS) exclusively found on the surface of the outer membrane. The surface layer of LPS contributes to the stringent permeability properties of the outer membrane, which is particularly resistant to permeation of many toxic compounds, including antibiotics. As a common surface antigen, LPS is recognized by host immune cells, which mount defences to ...[more]
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