Ontology highlight
ABSTRACT:
SUBMITTER: Spiegelberg L
PROVIDER: S-EPMC6913516 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Spiegelberg Linda L van Hoof Stefan J SJ Biemans Rianne R Lieuwes Natasja G NG Marcus Damiënne D Niemans Raymon R Theys Jan J Yaromina Ala A Lambin Philippe P Verhaegen Frank F Dubois Ludwig J LJ
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20190817
<h4>Background and purpose</h4>Esophageal cancer incidence is increasing and is rarely curable. Hypoxic tumor areas cause resistance to conventional therapies, making them susceptible for treatment with hypoxia-activated prodrugs (HAPs). We investigated in vivo whether the HAP evofosfamide (TH-302) could increase the therapeutic ratio by sensitizing esophageal carcinomas to radiotherapy without increasing normal tissue toxicity.<h4>Materials and methods</h4>To assess therapeutic efficacy, growth ...[more]