Ontology highlight
ABSTRACT:
SUBMITTER: Gorla M
PROVIDER: S-EPMC6913780 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Cell reports 20190301 12
Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. This switch prevents axons from re-entering the midline. In insects and mammals, negative regulation of Roundabout (Robo) receptors prevents premature response to the midline repellant Slit. In Drosophila, the endosomal protein Commissureless (Comm) prevents Robo1 surface expression before midline crossing by diverting Robo1 into late endosomes. Notably, Comm is ...[more]