Diagnostic accuracy of molecular detection of Mycobacterium tuberculosis in pediatric stool samples: A systematic review and meta-analysis.

ABSTRACT: Background:Stool is a promising specimen option to diagnose pediatric tuberculosis (TB), but studies have reported a wide range of test sensitivities. We conducted a meta-analysis to assess the accuracy of Xpert MTB/RIF or 'in-house' molecular tests on stool samples against culture or Xpert MTB/RIF on respiratory samples or clinically-diagnosed unconfirmed TB and aimed to identify factors that contribute to the heterogeneity of reported sensitivity.

Methods:We searched EMBASE and Pubmed databases and conference abstract books for studies reporting molecular stool testing against a clinical or microbiological reference standard among children.

Results:We identified 16 studies that included 2,481 children in stool test analyses. Pooled specificity was 98% [

SUBMITTER: Mesman AW 

PROVIDER: S-EPMC6914260 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature