Ontology highlight
ABSTRACT:
SUBMITTER: Zhao L
PROVIDER: S-EPMC6914413 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Zhao Long L Li Chenyu C Zhou Bin B Luo Congjuan C Wang Yanfei Y Che Lin L Zhao Jun J Xu Yan Y
Aging 20191127 22
<h4>Objective</h4>To explore the regulation and function of serum response factor (SRF) in epithelial-mesenchymal transition (EMT) in renal tubular epithelial cells (TECs) in hyperuricemic nephropathy (HN).<h4>Results</h4>In NRK-52E cells treated with UA and renal medulla tissue samples from hyperuricemic rats, SRF, fibronectin, α-SMA and FSP-1 expression was upregulated, while ZO-1 and E-cadherin expression was downregulated. SRF upregulation in NRK-52E cells increased slug expression. Blockade ...[more]