Ontology highlight
ABSTRACT:
SUBMITTER: Sato M
PROVIDER: S-EPMC6915080 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Sato Mitsuto M Takizawa Hotake H Nakamura Akinori A Turner Bradley J BJ Shabanpoor Fazel F Aoki Yoshitsugu Y
Frontiers in molecular neuroscience 20191205
Neuromuscular and neurodegenerative diseases are mostly modeled using genetically modified animals such as mice. However, animal models do not recapitulate all the phenotypes that are specific to human disease. This is mainly due to the genetic, anatomical and physiological difference in the neuromuscular systems of animals and humans. The emergence of direct and indirect human somatic cell reprogramming technologies may overcome this limitation because they enable the use of disease and patient ...[more]