Ontology highlight
ABSTRACT:
SUBMITTER: Quintero-Fabian S
PROVIDER: S-EPMC6915110 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Quintero-Fabián Saray S Arreola Rodrigo R Becerril-Villanueva Enrique E Torres-Romero Julio César JC Arana-Argáez Victor V Lara-Riegos Julio J Ramírez-Camacho Mario Alberto MA Alvarez-Sánchez María Elizbeth ME
Frontiers in oncology 20191206
During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the extracellular matrix (ECM), followed by endothelial cell migration, and proliferation and the new generation of matrix components. Matrix metalloproteinases (MMPs) participate in the disruption, tumor neovascularization, and subsequent metastasis while tissue inhibitors of metalloproteinases (TIMPs) downregulate the activity of these MMPs. T ...[more]