Subclinical inflammation and endothelial dysfunction are linked to cardiac autonomic neuropathy in type 2 diabetes.

ABSTRACT: Purpose:The present study aimed to examine association between inflammatory and endothelial function biomarkers and indices of cardiac autonomic control in T2DM patients. Methods:50 T2DM patients were recruited for this study. For cardiac autonomic function, cardiovascular autonomic reflex tests (CARTs) and heart rate variability (HRV) analysis was performed. Blood samples were collected for evaluating inflammatory and endothelial function biomarkers. Multivariable linear regression analysis adjusted for diabetes duration, glycemic control, waist circumference, hypertension, dyslipidemia, metformin, and statins was performed to examine the association between the biomarkers and cardiac autonomic function parameters. Results:Interleukin-6 was inversely related to total power (p =?.009) and low frequency power (p =?.04). Interleukin-18 and high sensitivity C-reactive protein inversely correlated with measures of cardiac vagal control (p?

SUBMITTER: Bhati P 

PROVIDER: S-EPMC6915244 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature