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Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation.

ABSTRACT: The hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry spatial information from the hippocampus to the ventral striatum. However, possible cross-structural communication between these two brain regions in memory formation has thus far been unknown. By selectively silencing the subiculum-ventral striatum pathway we found that its activity after learning is crucial for spatial memory consolidation and learning-induced plasticity. These results provide new insight into the neural circuits underlying memory consolidation and establish a critical role for off-line cross-regional communication between hippocampus and ventral striatum to promote the storage of complex information.

SUBMITTER: Torromino G

PROVIDER: S-EPMC6915753 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation.

Torromino G G Autore L L Khalil V V Mastrorilli V V Griguoli M M Pignataro A A Centofante E E Biasini G M GM De Turris V V Ammassari-Teule M M Rinaldi A A Mele A A

Nature communications 20191216 1

The hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry spatial information from the hippocampus to the ventral striatum. However, possible cross-structural communication between these two brain regions in memory formation has thus far been unknown. By selectively silencing the subiculum-ventral striatum pathway we found that its activity after learning is crucial for spatial memory consolidation and learning-ind ...[more]

PMID: 31844154

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