Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation.

ABSTRACT: The hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry spatial information from the hippocampus to the ventral striatum. However, possible cross-structural communication between these two brain regions in memory formation has thus far been unknown. By selectively silencing the subiculum-ventral striatum pathway we found that its activity after learning is crucial for spatial memory consolidation and learning-induced plasticity. These results provide new insight into the neural circuits underlying memory consolidation and establish a critical role for off-line cross-regional communication between hippocampus and ventral striatum to promote the storage of complex information.

SUBMITTER: Torromino G 

PROVIDER: S-EPMC6915753 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature