Considering the Role of Murine Double Minute 2 in the Cardiovascular System?
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ABSTRACT:
SUBMITTER: Lam B
PROVIDER: S-EPMC6916148 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Considering the Role of Murine Double Minute 2 in the Cardiovascular System?
Frontiers in cell and developmental biology 20191210
The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53-independent oncogenic function. These studies have contributed to designate MDM2 as a therapeutic target of choice for cancer treatment and the number of patents for MDM2 antagonists has increased immensely over the last years. However, the question of t ...[more]
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