Ontology highlight
ABSTRACT:
SUBMITTER: Helgadottir H
PROVIDER: S-EPMC6916246 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Helgadottir Hildur H Olsson Håkan H Tucker Margaret A MA Yang Xiaohong R XR Höiom Veronica V Goldstein Alisa M AM
Genetics in medicine : official journal of the American College of Medical Genetics 20171207 9
<h4>Purpose</h4>Carriers of CDKN2A mutations have high risks of melanoma and certain other cancers. In this study we examined the occurrence of tumors among CDKN2A wild type (wt) members of melanoma-prone families with CDKN2A mutations.<h4>Methods</h4>Swedish and US melanoma-prone families with CDKN2A mutations were included. Data was collected on tumors diagnosed among family members. Among the CDKN2A mutated families, members with CDKN2A wt status who were diagnosed with melanoma were designat ...[more]