Ontology highlight
ABSTRACT:
SUBMITTER: Portela M
PROVIDER: S-EPMC6917273 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Portela Marta M Venkataramani Varun V Fahey-Lozano Natasha N Seco Esther E Losada-Perez Maria M Winkler Frank F Casas-Tintó Sergio S
PLoS biology 20191217 12
Glioblastoma (GB) is the most lethal brain tumor, and Wingless (Wg)-related integration site (WNT) pathway activation in these tumors is associated with a poor prognosis. Clinically, the disease is characterized by progressive neurological deficits. However, whether these symptoms result from direct or indirect damage to neurons is still unresolved. Using Drosophila and primary xenografts as models of human GB, we describe, here, a mechanism that leads to activation of WNT signaling (Wg in Droso ...[more]