Dataset Information

Smoking trajectories and risk of stroke until age of 50 years - The Northern Finland Birth Cohort 1966.

ABSTRACT:

Background

Smoking is a well-known risk factor for stroke. However, the relationship between smoking trajectories during the life course and stroke is not known.

Aims

We aimed to study the association of smoking trajectories and smoked pack-years with risk of ischemic and haemorrhagic strokes in a population-based birth cohort followed up to 50 years of age.

Methods

Within the Northern Finland Birth Cohort 1966, 11,999 persons were followed from antenatal period to age 50 years. The smoking behaviour was assessed with postal questionnaires at ages 14, 31 and 46 years. Stroke diagnoses were collected from nationwide registers using unique study number linkage. The associations between smoking behaviour and stroke risk were estimated using Cox regression models.

Results

Six different patterns in smoking habits throughout the life course were found in trajectory modelling. During 542,140 person-years of follow-up, 352 (2.9%) persons had a stroke. Continuous smoking during the life course was associated with increased stroke risk (HR = 1.69; 95% CI 1.10-2.60) after adjusting for sex, educational level, family history of strokes, leisure-time physical activity, body mass index, alcohol consumption, hypertension, hypercholesterolemia, and diabetes. Per every smoked pack-year the stroke risk increased 1.04-fold (95% CI 1.03-1.06). Other smoking trajectories were not significantly associated with stroke risk, nor were starting or ending age of smoking.

Conclusion

Accumulation of smoking history is associated with increased risk of stroke until age of 50 years. The increased stroke risk does not depend on the age at which smoking started. Given that the majority starts smoking at young age, primary prevention of strokes should focus on adolescent smoking.

SUBMITTER: Rissanen I

PROVIDER: S-EPMC6917292 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Smoking trajectories and risk of stroke until age of 50 years - The Northern Finland Birth Cohort 1966.

Rissanen Ina I Oura Petteri P Paananen Markus M Miettunen Jouko J Geerlings Mirjam I MI

PloS one 20191217 12

<h4>Background</h4>Smoking is a well-known risk factor for stroke. However, the relationship between smoking trajectories during the life course and stroke is not known.<h4>Aims</h4>We aimed to study the association of smoking trajectories and smoked pack-years with risk of ischemic and haemorrhagic strokes in a population-based birth cohort followed up to 50 years of age.<h4>Methods</h4>Within the Northern Finland Birth Cohort 1966, 11,999 persons were followed from antenatal period to age 50 y ...[more]

PMID: 31846462

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Project description:BACKGROUND:Given the high global prevalence of physical inactivity, there is a need to design cities that support active modes of transportation. High density diverse neighborhoods with good access networks have been associated with enhanced walking and cycling, but there is a lack of large-scale longitudinal studies utilizing a life course perspective to model residential relocation trajectories. The objectives of the present longitudinal study were to model and visualize residential relocation trajectories between 31 and 46 years of age based on neighborhood density, mixed land use and access networks (DMA), and to assess neighborhood DMA as a predictor of self-reported regular walking and cycling and objectively measured physical activity. METHODS:Based on data from the Northern Finland Birth Cohort 1966 (N = 5947), we used self-reported regular walking and cycling and objectively measured physical activity as outcome variables and objectively assessed neighborhood DMA as the main explanatory variable. We conducted sequence analysis to model residential relocation trajectories, and generalized linear mixed models and Fisher's exact test were used to explore longitudinal associations between neighborhood DMA and physical activity. RESULTS:Over 80% of the participants lived in a neighborhood with the same level of neighborhood DMA during the follow-up. Relocation occurred more often from higher to lower DMA neighborhoods than reverse. Increased neighborhood DMA was associated with increased regular walking (OR 1.03; 95% CI: 1.00, 1.05; p = 0.023) and cycling (OR 1.17; 95% CI: 1.12, 1.23; p < 0.001). Residential relocation trajectory from lower to highest neighborhood DMA increased the odds of starting regular walking (OR 3.15; 95% CI: 1.50, 7.14; p = 0.001) and cycling (OR 2.63; 95% CI: 1.23, 5.79; p = 0.009) as compared to higher to lower neighborhood DMA trajectory. CONCLUSIONS:The results strongly support the hypothesis that increasing urban DMA can enhance regular walking and cycling at population level and so improve public health. The findings have implications for zoning and transportation policies, favoring the creation of dense and diverse neighborhoods with good access networks to support regular walking and cycling.

Dataset Information

Smoking trajectories and risk of stroke until age of 50 years - The Northern Finland Birth Cohort 1966.

Background

Aims

Methods

Results

Conclusion

Publications

Smoking trajectories and risk of stroke until age of 50 years - The Northern Finland Birth Cohort 1966.

Similar Datasets

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