Ontology highlight
ABSTRACT:
SUBMITTER: Pierce AM
PROVIDER: S-EPMC6917412 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Pierce Angela M AM Witt Davis A DA Donson Andrew M AM Gilani Ahmed A Sanford Bridget B Sill Martin M Van Court Benjamin B Oweida Ayman A Prince Eric W EW Steiner Jenna J Danis Etienne E Dorris Kathleen K Hankinson Todd T Handler Michael H MH Jones Kenneth L KL Karam Sana D SD Serkova Natalie J NJ Vibhakar Rajeev R Foreman Nicholas K NK Griesinger Andrea M AM
Neuro-oncology 20191201 12
<h4>Background</h4>Treatment for pediatric posterior fossa group A (PFA) ependymoma with gain of chromosome 1q (1q+) has not improved over the past decade owing partially to lack of clinically relevant models. We described the first 2 1q+ PFA cell lines, which have significantly enhanced our understanding of PFA tumor biology and provided a tool to identify specific 1q+ PFA therapies. However, cell lines do not accurately replicate the tumor microenvironment. Our present goal is to establish pat ...[more]