Ontology highlight
ABSTRACT:
SUBMITTER: Roper SI
PROVIDER: S-EPMC6917489 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Roper Sophie I SI Wasim Laabiah L Malinova Dessislava D Way Michael M Cox Susan S Tolar Pavel P
eLife 20191209
Antibody production depends on B cell internalization and presentation of antigens to helper T cells. To acquire antigens displayed by antigen-presenting cells, B cells form immune synapses and extract antigens by the mechanical activity of the acto-myosin cytoskeleton. While cytoskeleton organization driving the initial formation of the B cell synapse has been studied, how the cytoskeleton supports antigen extraction remains poorly understood. Here we show that after initial cell spreading, F-a ...[more]