Ontology highlight
ABSTRACT:
SUBMITTER: Germain E
PROVIDER: S-EPMC6917717 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Germain Elsa E Guiraud Paul P Byrne Deborah D Douzi Badreddine B Djendli Meriem M Maisonneuve Etienne E
Nature communications 20191217 1
The stringent response is a general bacterial stress response that allows bacteria to adapt and survive adverse conditions. This reprogramming of cell physiology is caused by the accumulation of the alarmone (p)ppGpp which, in Escherichia coli, depends on the (p)ppGpp synthetase RelA and the bifunctional (p)ppGpp synthetase/hydrolase SpoT. Although conditions that control SpoT-dependent (p)ppGpp accumulation have been described, the molecular mechanisms regulating the switching from (p)ppGpp deg ...[more]