Ontology highlight
ABSTRACT:
SUBMITTER: Nakano T
PROVIDER: S-EPMC6917750 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Nakano Toshihiro T Shiizaki Kazuhiro K Miura Yutaka Y Matsui Masahiro M Kosaki Keisei K Mori Shoya S Yamagata Kunihiro K Maeda Seiji S Kishi Takuya T Usui Naoki N Yoshida Masahide M Onaka Tatsushi T Mizukami Hiroaki H Kaneda Ruri R Karasawa Kazunori K Nitta Kosaku K Kurosu Hiroshi H Kuro-O Makoto M
Scientific reports 20191217 1
Circulating levels of fibroblast growth factor-21 (FGF21) start increasing in patients with chronic kidney disease (CKD) since early stages during the cause of disease progression. FGF21 is a liver-derived hormone that induces responses to stress through acting on hypothalamus to activate the sympathetic nervous system and the hypothalamus-pituitary-adrenal endocrine axis. However, roles that FGF21 plays in pathophysiology of CKD remains elusive. Here we show in mice that FGF21 is required to su ...[more]