The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery.
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ABSTRACT:
SUBMITTER: Yamamoto K
PROVIDER: S-EPMC6917768 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery.
Yamamoto Kotaro K Kokubun Taiki T Sato Kota K Akaishi Takahiro T Shimazaki Atsushi A Nakamura Masatsugu M Shiga Yukihiro Y Tsuda Satoru S Omodaka Kazuko K Saya Hideyuki H Nakazawa Toru T
Scientific reports 20191217 1
Treatments for refractory glaucoma include trabeculectomy, in which a filtering bleb is created to reduce aqueous pressure. Mitomycin C (MMC) is often used as an adjuvant to reduce post-trabeculectomy bleb scarring and consequent failure. However, scarring sometimes still occurs. Thus, we searched for more effective trabeculectomy adjuvants with high-throughput screening (HTS) of a library of 1,165 off-patent drug compounds. This revealed that amsacrine (AMSA), a DNA topoisomerase II (TOP2) inhi ...[more]
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