Ontology highlight
ABSTRACT:
SUBMITTER: Iwakawa N
PROVIDER: S-EPMC6917819 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Iwakawa Naoto N Baxter Nicola J NJ Wai Dorothy C C DCC Fowler Nicholas J NJ Morales Rodrigo A V RAV Sugase Kenji K Norton Raymond S RS Williamson Mike P MP
Scientific reports 20191217 1
ShK is a 35-residue disulfide-linked polypeptide produced by the sea anemone Stichodactyla helianthus, which blocks the potassium channels Kv1.1 and Kv1.3 with pM affinity. An analogue of ShK has been developed that blocks Kv1.3 > 100 times more potently than Kv1.1, and has completed Phase 1b clinical trials for the treatment of autoimmune diseases such as psoriasis and rheumatoid arthritis. Previous studies have indicated that ShK undergoes a conformational exchange that is critical to its func ...[more]