Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC6917869 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20191108 52
Small-molecule crosslinkers are invaluable for probing biomolecular interactions and for crosslinking mass spectrometry. Existing chemical crosslinkers target only a small selection of amino acids, while conventional photo-crosslinkers target almost all residues non-specifically, complicating data analysis. Herein, we report photocaged quinone methide (PQM)-based crosslinkers that target nine nucleophilic residues through Michael addition, including Gln, Arg, and Asn, which are inaccessible to e ...[more]