Ontology highlight
ABSTRACT:
SUBMITTER: Nagao RJ
PROVIDER: S-EPMC6918119 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20191016 24
Vascularization remains an obstacle when engineering complex tissues for regeneration and disease modeling. Although progress has been made in recreating 3D vascular structures, challenges exist in generating a mature, functional endothelium. It is demonstrated that perfusing engineered microvessels with platelet-rich plasma, a critical homeostatic component in vivo that is often overlooked in vitro, substantially transforms the endothelium, both maturing endothelial cells and improving function ...[more]