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Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism.

ABSTRACT: There have been numerous recent advances in wound care management. Nevertheless, the assessment of hemostatic dressing is essential to enable surgeons and other physicians and healthcare professionals to make the correct decisions regarding the disposition of severe hemorrhage. Here, we investigated the relative efficacies of chitosan-based and conventional gauze dressings in a rat model of femoral artery hemorrhage and in patients with surgical wounds. Dressing effectiveness was evaluated based on hemostatic profiles, biocompatibility, antimicrobial activity, and blood factor responses in coagulation. Relative to standard gauze dressing, the chitosan fiber (CF) dressing treatment significantly shortened the time to hemostasis in injured rats. Moreover, the CF dressing significantly prolonged partial thromboplastin time, enhanced blood absorption, and reduced antithrombin production without altering the prothrombin ratio. Unlike regular gauze bandages, the CF dressing demonstrated remarkable antibacterial activity. The results of this study indicate the effectiveness of chitosan as a hemostatic dressing and elucidate its underlying mechanism. It is possible that chitosan surgical dressings could serve as first-line intervention in hospital emergency care for uncontrolled hemorrhage.

SUBMITTER: Wang YW

PROVIDER: S-EPMC6918334 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism.

Wang Yi-Wen YW Liu Chuan-Chieh CC Cherng Juin-Hong JH Lin Chien-Seng CS Chang Shu-Jen SJ Hong Zhi-Jie ZJ Liu Cheng-Che CC Chiu Yaw-Kwan YK Hsu Sheng-Der SD Chang And Hung AH

Polymers 20191119 11

There have been numerous recent advances in wound care management. Nevertheless, the assessment of hemostatic dressing is essential to enable surgeons and other physicians and healthcare professionals to make the correct decisions regarding the disposition of severe hemorrhage. Here, we investigated the relative efficacies of chitosan-based and conventional gauze dressings in a rat model of femoral artery hemorrhage and in patients with surgical wounds. Dressing effectiveness was evaluated based ...[more]

PMID: 31752424

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Dataset Information

Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism.

Publications

Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism.

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