Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC6918510 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Chen Jinmiao J Ma Qing Q King Justin S JS Sun Yan Y Xu Bing B Zhang Xiaoyu X Zohrabian Sylvia S Guo Haipeng H Cai Wenqing W Li Gavin G Bruno Ivone I Cooke John P JP Wang Chunsheng C Kontaridis Maria M Wang Da-Zhi DZ Luo Hongbo H Pu William T WT Lin Zhiqiang Z
Life science alliance 20191216 1
Myocardial recovery from ischemia-reperfusion (IR) is shaped by the interaction of many signaling pathways and tissue repair processes, including the innate immune response. We and others previously showed that sustained expression of the transcriptional co-activator yes-associated protein (YAP) improves survival and myocardial outcome after myocardial infarction. Here, we asked whether transient YAP expression would improve myocardial outcome after IR injury. After IR, we transiently activated ...[more]