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A NIR-emitting cyanine with large Stokes shifts for live cell imaging: large impact of the phenol group on emission.

ABSTRACT: There are a limited number of near-infrared (NIR) emitting (?em = 700-900 nm) molecular probes for imaging applications. A NIR-emitting probe that exhibits emission at ?800 nm with a large Stokes shift was synthesized and found to exhibit excellent selectivity towards mitochondria for live-cell imaging. The photophysical properties were attributed to an excited "cyanine structure" via intramolecular charge transfer (ICT) involving a phenol group.

SUBMITTER: Dahal D

PROVIDER: S-EPMC6918678 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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A NIR-emitting cyanine with large Stokes shifts for live cell imaging: large impact of the phenol group on emission.

Dahal Dipendra D McDonald Lucas L Pokhrel Sabita S Paruchuri Sailaja S Konopka Michael M Pang Yi Y

Chemical communications (Cambridge, England) 20191001 88

There are a limited number of near-infrared (NIR) emitting (λem = 700-900 nm) molecular probes for imaging applications. A NIR-emitting probe that exhibits emission at ∼800 nm with a large Stokes shift was synthesized and found to exhibit excellent selectivity towards mitochondria for live-cell imaging. The photophysical properties were attributed to an excited "cyanine structure" via intramolecular charge transfer (ICT) involving a phenol group. ...[more]

PMID: 31595909

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