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GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.

ABSTRACT: Alcohol dependence (AD) and nicotine dependence (ND) co-occur frequently (AD+ND). We integrated SNP-based, gene-based, and protein-protein interaction network analyses to identify shared risk genes or gene subnetworks for AD+ND in African Americans (AAs, N?=?2,094) and European Americans (EAs, N?=?1,207). The DSM-IV criterion counts for AD and ND were modeled as two dependent variables in a multivariate linear mixed model, and analyzed separately for the two populations. The most significant SNP was rs6579845 in EAs (p?

SUBMITTER: Xiang B 

PROVIDER: S-EPMC6918694 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.

Xiang Bo B   Yang Bao-Zhu BZ   Zhou Hang H   Kranzler Henry H   Gelernter Joel J  

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20181128 1

Alcohol dependence (AD) and nicotine dependence (ND) co-occur frequently (AD+ND). We integrated SNP-based, gene-based, and protein-protein interaction network analyses to identify shared risk genes or gene subnetworks for AD+ND in African Americans (AAs, N = 2,094) and European Americans (EAs, N = 1,207). The DSM-IV criterion counts for AD and ND were modeled as two dependent variables in a multivariate linear mixed model, and analyzed separately for the two populations. The most significant SNP  ...[more]

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