GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.
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ABSTRACT:
SUBMITTER: Xiang B
PROVIDER: S-EPMC6918694 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.
Xiang Bo B Yang Bao-Zhu BZ Zhou Hang H Kranzler Henry H Gelernter Joel J
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20181128 1
Alcohol dependence (AD) and nicotine dependence (ND) co-occur frequently (AD+ND). We integrated SNP-based, gene-based, and protein-protein interaction network analyses to identify shared risk genes or gene subnetworks for AD+ND in African Americans (AAs, N = 2,094) and European Americans (EAs, N = 1,207). The DSM-IV criterion counts for AD and ND were modeled as two dependent variables in a multivariate linear mixed model, and analyzed separately for the two populations. The most significant SNP ...[more]
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