Ontology highlight
ABSTRACT:
SUBMITTER: Zheng W
PROVIDER: S-EPMC6919330 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Zheng Wei W Zhang Hui H Zhao Dejian D Zhang Jinghang J Pollard Jeffrey W JW
Cell reports 20191101 7
The tumor microenvironment (TME) at the metastatic site consists of multiple components with considerable cellular heterogeneity. To test whether endothelial cells (ECs) associated with lung metastases express a distinct gene expression program that promotes metastatic growth, we isolated CD31<sup>+</sup>/CD45<sup>-</sup> cells from lung mammary cancer metastases for RNA sequencing and found CD44 upregulation. Unexpectedly, the CD44<sup>+</sup> subset did not comprise authentic ECs nor were they ...[more]