Unknown

Dataset Information

0

Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia.


ABSTRACT: BACKGROUND:FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G?>?A (rs2234767) and FAS-670A?>?G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian population while the outcomes are inconsistent. To derive a more precise assessment of the association between breast cancer susceptibility with FAS gene promoter SNPs, a meta-analysis of published studies was performed. MATERIAL AND METHODS:We systematically searched PubMed, Embase, Web of Science, and the Chinese biomedical database (CBM) for papers published until November 1, 2018. Odds ratio (OR) with 95% confidential interval (95%CI) was conducted to evaluate the associations. Statistical analysis was conducted using Stata13.0 software. A total of 8 studies covering 2564 cases and 2633 controls were included. RESULTS:The integrated results suggest the following: For the FAS-1377G/A polymorphism, we only found significant associations for allele G vs allele A (OR?=?1.100, 95%CI?=?1.004-1.206, P?=?.040). After stratification by ethnicity, a significant association was observed only for the AA+GA vs GG genotype in East Asian populations (OR?=?1.177, 95% CI?=?1.010-1.371, P?=?.037). The association was not found in West Asian populations. For the FAS -670A/G polymorphism, no association with cancer risk was found in any comparison model. Sensitivity analysis suggests that the meta-analysis results obtained after excluding any single study were similar to the original ones, suggesting that the meta-analysis results were not significantly affected by any single study. CONCLUSION:These results indicated that FAS-1377G/A polymorphism may contribute to the increased breast cancer susceptibility and could be a promising target for cancer risk prediction. Further studies are needed to determine if the FAS gene confers a risk of breast cancer in other ethnic groups, such as Africans and Latin Americans.

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6919540 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia.

Chen Ying Y   Wang Hanfei H   Yan Yunwen Y   Ren Min M   Yan Cunye C   Wang Benzhong B  

Medicine 20191201 49


<h4>Background</h4>FAS cell surface death receptor (FAS) gene has 2 common single nucleotide polymorphisms (SNPs) in its promoter, FAS-1377G > A (rs2234767) and FAS-670A > G (rs1800682). Several studies have investigated the role of these 2 polymorphisms in etiology of breast cancer in Asian population while the outcomes are inconsistent. To derive a more precise assessment of the association between breast cancer susceptibility with FAS gene promoter SNPs, a meta-analysis of published studies w  ...[more]

Similar Datasets

| S-EPMC7896729 | biostudies-literature
| S-EPMC3311588 | biostudies-literature
| S-EPMC4610046 | biostudies-literature
| S-EPMC5746410 | biostudies-other
| S-EPMC6133630 | biostudies-literature
| S-EPMC4503171 | biostudies-literature
| S-EPMC7310827 | biostudies-literature
| S-EPMC5488229 | biostudies-literature
| S-EPMC7891528 | biostudies-literature
| S-EPMC5342380 | biostudies-literature