Ontology highlight
ABSTRACT:
SUBMITTER: Reyes M
PROVIDER: S-EPMC6919553 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Advanced biosystems 20190828 11
Profiling multiple omic layers in a single cell enables the discovery and analysis of biological phenomena that are not apparent from analysis of mono-omic data. While methods for multi-omic profiling have been reported, their adoption has been limited due to high cost and complex workflows. Here, we present a simple method for joint profiling of gene expression and chromatin accessibility in tens to hundreds of single cells. We assess the quality of resulting single cell ATAC- and RNA-seq data ...[more]