Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.

ABSTRACT:

Background

Habitual alcohol use can be an indicator of alcohol dependence, which is associated with a wide range of serious health problems.

Methods

We completed a genome-wide association study in 126,936 European American and 17,029 African American subjects in the Veterans Affairs Million Veteran Program for a quantitative phenotype based on maximum habitual alcohol consumption.

Results

ADH1B, on chromosome 4, was the lead locus for both populations: for the European American sample, rs1229984 (p = 4.9 × 10^-47); for African American, rs2066702 (p = 2.3 × 10^-12). In the European American sample, we identified three additional genome-wide-significant maximum habitual alcohol consumption loci: on chromosome 17, rs77804065 (p = 1.5 × 10^-12

SUBMITTER: Gelernter J 

PROVIDER: S-EPMC6919570 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature